Common Side Effects:
1. Gastrointestinal Issues:
- ○ Nausea: A common side effect, especially when starting the medication. This tends to improve over time as the body adjusts.
- ○ Vomiting: Some people may experience vomiting, particularly during the initial stages of treatment.
- ○ Diarrhea or Constipation: These can occur, with some people experiencing one more than the other.
- ○ Abdominal Pain: Stomach discomfort or pain is also reported by some users.
2. These gastrointestinal side effects tend to be temporary but can be bothersome for some people. Doctors often recommend starting with a lower dose and gradually increasing to help minimize these symptoms.
3. Decreased Appetite
- ○ While this is a desired effect for many, some people may experience it too strongly, leading to reduced food intake and potential issues like fatigue or weakness.
Less Common but Serious Side Effects:
1. Thyroid Tumors (Including Medullary Thyroid Cancer):
- ○ Potential Risk: Similar to other GLP-1 receptor agonists, retatrutide may carry a risk of thyroid tumors, including medullary thyroid cancer (MTC), and a possible increased risk of developing certain types of thyroid conditions.
- ○ Caution for those with a Family History: It is especially not recommended for people with a family history of MTC or multiple endocrine neoplasia syndrome type 2 (MEN 2).
2. Pancreatitis (Inflammation of the Pancreas):
- ○ Symptoms: Severe abdominal pain, nausea, and vomiting could indicate pancreatitis. If this happens, the drug should be discontinued immediately, and medical attention sought.
3. Kidney Problems:
- ○ Dehydration Risk: If nausea, vomiting, or diarrhea are severe, dehydration could occur, which may lead to kidney problems. People with preexisting kidney conditions may need to be more cautious.
4. Low Blood Sugar (Hypoglycemia):
- ○ This is more likely to occur if Retatrutide is used in combination with other diabetes medications that lower blood sugar, such as insulin or sulfonylureas.
- ○ Symptoms: Shaking, sweating, dizziness, and confusion are signs of low blood sugar.
5. Allergic Reactions:
- ○ Symptoms: Rash, itching, swelling, or difficulty breathing could indicate an allergic reaction. In severe cases, this could lead to anaphylaxis (a life-threatening reaction), though this is rare.
6. Gallbladder Problems:
- ○ Gallstones: There is a potential risk of developing gallstones, which could lead to pain in the upper abdomen, nausea, and vomiting.
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